Activity-dependent neuronal signalling and autism spectrum disorder

Danial H. Ebert & Michael E. Greenberg, Activity-dependent neuronal signalling and autism spectrum disorder, Nature 493 (2013)

Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity.

Neuronal activity triggers local changes at the synapse, altering the composition, shape and strength of the synapse. Synaptic stimulation both induces specific changes in messenger RNA translation near synapses and sends signals to the nucleus to induce gene transcription programs that control synaptic maturation and function.

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