TelomereHunter: telomere content estimation and characterization from whole genome sequencing data

Lars Feuerbach, et al., TelomereHunter: telomere content estimation and characterization from whole genome sequencing data, bioRxiv, 2016

Here, we present TelomereHunter, a new computational tool for determining telomere content that is specifically designed for matched tumor and control pairs. In contrast to existing tools, TelomereHunter takes alignment information into account and reports the abundance of variant repeats in telomeric sequences.

 

The criterion of searching for six non-consecutive repeats in 100bp long reads has been proposed previously (Lee, et al., 2014) and was also found suitable for the data presented in the present study.

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